T cell stimulation by dendritic cell-tumor cell hybrids is enhanced in the presence of free dendritic cells

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T cell stimulation by dendritic cell-tumor cell hybrids is enhanced in the presence of free dendritic cells

Dendritic cell-tumor cell hybrids (heterokaryons) are under investigation as a means for tumor immunotherapy since they should express MHC class I molecules from both cell types and, thus, present tumor antigens within an immunogenic context. The aim of this work was, therefore, to evaluate, in vitro, the immunostimulatory potential of these heterokaryons. To generate the hybrids, mature dendri...

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ژورنال

عنوان ژورنال: Journal for ImmunoTherapy of Cancer

سال: 2013

ISSN: 2051-1426

DOI: 10.1186/2051-1426-1-s1-p232